Cholinesterase Inhibitors

Date: 2015-10-07; view: 752.

Cholinomimetic Drugs and

1. During operation the anaesthesiologist has overdosed tubocurarine chloride to patient. Proserine has been prescribed. What is the base of action proserine in this case?

*A. Inhibition of cholinesterase activity.

B. Increase of cholinesterase activity.

C. Blockade of presynaptic membrane.

D. Stimulation of M-cholinoceptors.

E. Blockade of adrenoceptors.

2. A patient is delivered into hospital with complaints of dizziness, decrease of vision acuteness, nausea, hypersalivation, and abdominal cramps. The diagnosis is poisoning with organophosphorus compounds. What drugs should be included in complex therapy?

*A. Atropine sulfate and dipyroxime.

B. Thiosulfate sodium and bemegride.

C. EDTA.

D. Naloxone and bemegride.

E. Glucose and bemegride.

3. A patient with complaints of dry mouth and skin, vision disturbances, mydriasis, and tachycardia has been delivered into hospital. The doctor has put the diagnosis of poisoning with Belladonna's alkaloids. What drug should be prescribed?

*A. Proserinum (neostigmine).

B. Aceclidine.

C. Pilocarpine.

D. Armin.

E. Dipyroxime.

4. Residual phenomena is observed in a child after poliomyelitis. What drug should be prescribed in this case?

*A. Galanthamine.

B. Pentaminum (azamethonium).

C. Dimecoline.

D. Atropine sulfate.

E. Pyrroxane.

5. A victim processed the plant by insecticides without the individual means of protection. After some time the following symptoms were developed in him: hypersalivation, sweating, diarrhoea, miosis, and pain in the abdomen. The drug, which has caused this poisoning, is included to the group of:

*A. Cholinesterase inhibitors.

B. N-cholinomimetics.

C. Cuprum salts.

D. Nitrates.

E. Organic chloride compounds.

6. After the dropping of drops of some drug into eyes the miosis and short-sightedness has developed in patient with glaucoma. The intraocular pressure has decreased. What group of drug can cause such effect?

*A. M-cholinomimetics.

B. M-cholinoblockers.

C. a-adrenomimetics.

D. N-cholinomimetics.

E. Ganglioblockers.

7. Paresis of intestine has developed in patient after surgery. What drug from group of cholinesterase inhibitors should be prescribed to this patient?

*A. Proserinum.

B. Carbacholine.

C. Aceclidine.

D. Pilocarpine.

E. Acetylcholine.

8. A 5-year-old child has been delivered to emergency department with the following symptoms: marked psychomotor excitation, delirium, hallucinations, hoarse voice, dilatation of pupils, hyperaemia of the skin, tachycardia, tachypnoa. These symptoms were developed after the child has used the berries of belladonna. What group of drug should be prescribed for treatment of the child?

*A. Cholinesterase inhibitors.

B. N-cholinomimetics.

C. M-cholinomimetics.

D. N-cholinoblockers.

E. Cholinesterase regenerators.

9. The disturbances of breathing had developed in patient during the operation with the use of peripheral myorelaxants. The administration of proserinum improves the patient's condition. What is such interaction of drugs called?

*A. Antagonism.

B. Synergism.

C. Incompatibility.

D. Tachyphylaxis.

E. Cumulation.

10. A 4-year-old boy was delivered to toxicological department with poisoning by berries of belladonna. What drug should be prescribed to boy in this condition?

*A. Galantamine

B. Aceclidine

C. Lobeline

D. Cytitonum

E. Platyphyllin

11. The peristaltic of intestine was not restored in patient after resection of stomach. What drug should be prescribed to patient for stimulation of GI-tract function?

*A. Proserinum (neostigmine).

B. Platyphyllin.

C. Cyclodolum.

D. Atropine.

E. Dithylinum.

12. A patient with complaints of weakness and disturbances of gait came to the doctor. The doctor has diagnosed myasthenia and prescribed to the patient the injection of proserinum. What is mechanism of proserinum action?

*A. Inhibition of cholinesterase.

B. Direct stimulation of cholinoceptors.

C. Stimulation of metabolic processes.

D. Inhibition of brake processes.

E. Activation of acetylcholine synthesis.

13. A 40-year-old male was delivered to toxicological department with poisoning by insecticides. What cholinesterase regenerator drug should be prescribed to patient?

*A. Dipyroxime.

B. Platyphyllin.

C. Scopolamine.

D. Amizylum.

E. Atropine.

14. What drug, which can cause miosis, will keep the action in animal with denervation of smooth muscles of eye?

*A. Pilocarpine.

B. Galantamine.

C. Proserinum.

D. Prazosin.

E. Reserpine.

15. A female was received injections of galantamine for restoration of CNS functions after ischaemic stroke. The condition of female was significantly improved. What is the mechanism of this drug action?

*A. Blockade of cholinesterase.

B. Blockade of cholinoceptors.

C. Blockade of catechol-ortho-methyltransferase.

D. Blockade of dopaminehydroxylase.

E. Blockade of monoamine oxidase.

16. A 65-year-old male is accepted in neurological department with postinsult syndrome. What drug should be prescribed for acce-leration of this patient recovery?

*A. Galantamine hydrobromide.

B. Ipratropium bromide.

C. Dipyroxime.

D. Isonitrosine.

E. Aceclidine.

17. Drug A. was prescribed to patient with myasthenia and caused the improving of muscles activity. But several side effects had developed gradually: hypersalivation, sweating, diarrhoea, nausea. What drug was used for treatment of the patient?

*A. Proserinum (neostigmine).

B. Analginum (metamizole).

C. Strychnine.

D. Caffeine.

E. Armin.

18. A physician has prescribed eye drops with proserinum to patient for decrease of intraocular pressure. What is the mechanism of proserinum action?

*A. Blockade of cholinesterase.

B. Blockade of cyclooxygenase.

C. Blockade of lipoxygenase.

D. Blockade of phosphodiesterase.

E. Blockade of phospholypase.

19. The victim was delivered to emergency department with complaints of dryness in mouth, photophobia, and disturbances of vision. Hyperaemia, dryness of skin, and tachycardia are observed. The diagnosis is the poisoning with alkaloids of Belladonna. What drug should be prescribed?

*A. Proserinum.

B. Diazepam.

C. Pilocarpine.

D. Armin.

E. Dipyroxime.

20. The atony of intestine has developed in patient on the 3^rd day after resection of stomach. What drug should be used?

*A. Proserinum.

B. Atropine sulfate.

C. Benzohexonium (hexamethonium).

D. No-spa (drotaverine).

E. Pirilenum.

21. A 2-year-old child has had a drink of eye drops from the first-aid set. The child has significant sweating and hypersalivation, difficult breathing, and cough. The pupils are narrowed and bradycardia is observed. The peristaltic of intestine is increased. The blood pressure is low. What drug has caused poisoning?

*A. Pilocarpine hydrochloride.

B. Propranolol (anaprilinum).

C. Atropine.

D. Platyphyllin.

E. Sulfacylum-sodium.

22. A patient was delivered to emergency department with such symptoms: miosis, hypersalivation, sweating, vomiting diarrhoea, and spasm of bronchi. The diagnosis of poisoning with organophosphorus substances was ascertained. What drugs should be included in complex therapy?

*A. Atropine sulfas and dipyroxime.

B. Thiosulfate sodium and bemegride.

C. Nalorphine hydrochloride and bemegride.

D. Glucose and bemegride.

E. Panangin and unithiole.

23. Analeptical remedy of reflective type from the H-cholinomimetics group was given to the patient for restoration of breathing after poisoning with carbon monooxide. What medicine was prescribed to the patient?

*A. Lobeline hydrochloride.

B. Mesaton.

C. Adrenaline hydrochloride.

D. Pentamin.

E. Atropine sulphate.

24. A 50-year-old male farm worker has been brought to the emergency room. He was found confused in the orchard and since then has remained unconscious. His heart rate is 45 and his blood pressure is 80/40 mm Hg. He is sweating and salivating profusely. Which of the following should be prescribed?

*A. Atropine.

B. Proserine.

C. Physostigmine.

D. Noradrenaline.

E. Pentamine.

25. A child has residual phenomena after poliomyelitis. What drug is to be prescribed?

*A. Galanthamini hydrobromidum.

B. Pentaminum.

C. Dimecolinum.

D. Atropini sulfas.

E. Pyroxanum.

26. An injection of galanthamine hydrobromide was made to a woman, 63-year-old, after ischaemic stroke. Condition of the patient has considerably improved. What is the mechanism of this medication effect?

*A. Inhibition of acetylcholinesterase.

B. Inhibition of cholinergic receptors.

C. Inhibition of catechol-orto-methyltranspherase.

D. Inhibition of dopamine-hydroxylase.

E. Inhibition of monoamine oxidase.

27. It is necessary to prescribe a medication to a patient with glaucoma diagnosis. Which anticholinesterase drug (tertiary amine) isn't used in ophthalmologic practice due to its irritative influence on the eye conjunctiva?

*A. Galanthamini hydrobromidum.

B. Pyridostigmini bromidum.

C. Phosphacolum.

D. Proserinum.

E. Arminum.

28. A patient with myasthenia was prescribed a drug which improved muscle performance. But a number of defects have been revealed gradually: intensive salivation, transpiration, diarrhoea, nausea. What drug was used for treatment?

*A. Proserinum.

B. Analginum.

C. Strychnini nitras.

D. Coffeinum-natrii benzoas.

E. Arminum.

29. A 25-year-old man appeals to neurologist with complaints of weakness in legs and gait disorder. The doctor diagnoses myasthenia and prescribes to patient an injection of proserin. What is typical action of this drug?

*A. Prevention of acetylcholine destruction.

B. Direct cholinomimetic.

C. Stimulation of metabolic processes.

D. Ganglion blocking.

E. Activation of acetylcholine synthesis.

30. A child poisoned with mushrooms, namely fly agarics, has been taken to a toxicological department. What drug should be used for emergency first of all?

*A. Atropini sulfas.

B. Papaverini hydrochloridum.

C. Unithiolum.

D. Natrii thiosulfas.

E. Dipiroxinum.

31. A child, 2-years-old, has drunk eye drops from the domestic first-aid kit. The child's condition is poor, accompanied by transpiration and salivation, asthmatic breathing, cough, sharply miotic pupils, muffled heart sounds, bradycardia, low arterial pressure, intensive intestinal peristalsis, diarrhea. What is the drug which has caused the poisoning?

*A. Pilocarpini hydrochloridum.

B. Propranololum.

C. Atropini sulfas.

D. Platyphyllini hydrotartras.

E. Sulfacylum-natrium.

32. A victim treated plants with an insecticidal solution without personal protection equipment. After a while, salivation, transpiration, tears secretion, pain in the stomach, and diarrhoea began. Examination revealed miosis. What group does the substance, which has caused such symptoms, belong to?

*A. Organic compounds of phosphorus.

B. N-cholinomimetics.

C. Copper salt.

D. Nitrates.

E. Organic compounds of chlorine.

33. Having used eye drops, a patient with glaucoma has developed miosis and myopia, intraocular pressure has decreased. What group of drugs causes such effect?

*A. M-cholinomimetics.

B. M-cholinergic blockers.

C. a-adrenergic blockers.

D. N-cholinomimetics.

E. Ganglionic blockers.

34.An 18-year-old unconsciousness patient was delivered to urgent unit with signs of dry skin and widened pupils. It is known, that patient has poisoned with berries of belladonna which containing M-cholinoblocker atropine. What drug should be prescribed to patient?

*A. Proserinum.

B. Adrenaline.

C. Pilocarpine.

D. Anaprilinum.

E. Platyphyllin.

35.A victim with acute poisoning by fly-agaric was delivered to urgent department. What drug should be prescribed to him?

*A. Atropine sulfate.

B. Dithylinum.

C. Diazolinum.

D. Furacilinum.

E. Omeprazole.

36.The agent which decreases intraocular pressure is prescribed to patient with glaucoma. Indicate this agent.

*A. Proserinum.

B. Noradrenaline.

C. Phenazepam.

D. Analginum.

E. Penicillin.

37.Paralysis of bladder muscles has developed in patient owing to surgery. What group of drugs should be prescribed to this patient?

*A. Cholinesterase inhibitors.

B. Diuretics.

C. Antibiotics.

D. Adrenoblockers.

E. Antianginal drugs.