M-Cholinoblocking Drugs
Date: 2015-10-07; view: 1040.
1. Laryngospasm and hypersalivation have developed in patient after introduction of thiopental sodium for initial anaesthesia. The previous introduction of what drug can prevent the development of these side effects?
*A. Atropine sulfate.
B. Proserinum.
C. Alloxime.
D. Pyrroxane.
E. Epinephrine hydrochloride.
2. A patient was delivered to emergency department with poisoning by mushrooms, among which fly-agaric has casually appeared. The injection of atropine sulfate was prescribed to patient except the gastric lavage, active carbon, saline laxative drugs, and infusion therapy. Name a type of interaction between the atropine and muscarine.
*A. Direct functional one-way antagonism.
B. Indirect functional antagonism.
C. Intermediary antagonism.
D. Chemical antagonism.
E. Physicochemical antagonism.
3. Nausea, vomiting, diarrhoea, and twitching of skeletal muscles developed in patient with myasthenia after administration of proserinum. What drug can eliminate these symptoms?
*A. Atropine.
B. Physostigmine.
C. Pyridostigmine bromide.
D. Isadrinum (isoprenaline).
E. Mesatonum (phenylephrine).
4. As a rule, the attacks of bronchial asthma develop in patient at night, and are accompanied by bradycardia, spastic pain of intestine, and diarrhoea. What group of drug can eliminate these symptoms?
*A. M-cholinoblockers.
B. N-cholinoblockers and blockers of H2-histamine receptors.
C. a-adrenoblockers.
D. b-adrenoblockers.
E. Sympatholytics.
5. It is necessary to expand the pupils for examination of the eye fundus. Call the drug, which is used for this purpose in clinic.
*A. Atropine.
B. Pilocarpine.
C. Ezerinum.
D. Adrenaline.
E. Acetylcholine.
6. The drugs of this group are used for decrease of salivary glands secretion, prevention of laryngospasm, nausea, and bradycardia. Call this group.
*A. M-cholinoblockers.
B. Myorelaxants.
C. M-cholinomimetics.
D. Inhibitors of cholinesterase.
E. Cholinesterase regenerators.
7. Bronchospasm has developed in worker as a result of careless using of organophosphorus substances. What broncholytic should be used in this situation?
*A. Atropine.
B. Berotec (fenoterol).
C. Euphyllinum (aminophylline).
D. Adrenaline.
E. Ephedrine.
8. Atropine is used as antidote in case of poisoning with fly-agaric mushrooms. What is the mechanism of atropine action, which causes the elimination of toxic effects of muscarine?
*A. Competition for same receptors
B. Physico-chemical
C. Anti-enzymatic
D. Metabolic
E. Enzymatic
9. A 48-year-old male was delivered to urologic department with symptoms of renal colic. Choose a drug, which is most rational in this case.
*A. Atropine.
B. Morphine.
C. Analginum (metamizole).
D. Promedolum (trimeperidine).
E. Fenthanyl.
10. The decrease of salivation and expansion of pupils are developed in experimental animal after introduction of drug A. After following intravenous administration of acetylcholine the heart rate has not changed. Call the drug A.
*A. Atropine.
B. Adrenaline.
C. Anaprilinum (propranolol).
D. Proserinum.
E. Salbutamol.
11. A female with glaucoma asked the pharmacist with the request to give out to her eye drops with atropine sulfate. But pharmacist has explained her that this drug is contraindicated for her. Why atropine is contraindicated in glaucoma?
*A. It causes increase of intraocular pressure.
B. It causes paralysis of accommodation.
C. It causes expansion of pupils.
D. It reduces acuteness of vision.
E. It oppresses eye reflexes.
12. A patient was delivered to the hospital with the following symptoms: dizziness, thirst, impairment of swallowing, bad vision of near subjects. Patient has tachypnoe, expanded pupils, and excitement. The blood pressure is 110/70 mm Hg, heart rate is 110 per 1 minute. These symptoms testify overdose of:
*A. Atropine.
B. Morphine.
C. Ephedrine.
D. Aminazinum (chlorpromazine).
E. Caffeine.
13. Mydriasis and paralysis of accommodation have developed in patient after dropping into eyes the solution of drug A. Call the group, to which the drug A. concerns.
*A. M-cholinoblockers.
B. M-cholinomimetics.
C. Cholinesterase inhibitors.
D. b-adrenomimetics.
E. a-adrenomimetics.
14. A patient, who receives the treatment concerning bronchial asthma, also suffers from glaucoma. The drugs of which group are not recommended to this patient for treatment of asthma?
*A. M-cholinoblockers.
B. Adrenomimetics.
C. Miotropic spasmolytics.
D. Glucocorticoids.
E. Adrenoblockers.
15. Atropine sulfate was prescribed to patient for interruption of intestine colic. What disease is contraindication for administration of atropine?
*A. Glaucoma.
B. Bronchial asthma.
C. Node tachycardia.
D. Hypotension.
E. Dizziness.
16. A 6-year-old child was delivered to hospital with markedly expressed symptoms of psychomotor excitement, impairment swallowing, and hoarse voice. The skin is dry and hot. The pupils are expended. Tachycardia is observed. The doctor has established, that child had taken some berries of dark-violet colour. What substance is the cause of poisoning?
*A. Atropine.
B. Pirenzepine.
C. Pilocarpine.
D. Platyphyllin.
E. Metacinum.
17. It is necessary to prescribe M-cholinoblocker for patient who suffers from ulcer disease of stomach (with hyperacidic syndrome) and glaucoma. What drug may be prescribed to this patient?
*A. Metacinium.
B. Spasmolytinum (adiphenine).
C. Atropine.
D. Scopolamine.
E. Homatropine.
18. The increase of heart rate, mydriasis, and significant dryness of mucous membranes has developed in patient after introduction of atropine. What drug should be prescribed to patient for reduction of these symptoms?
*A. Proserinum.
B. Metacinium.
C. Salbutamol.
D. Ephedrine hydrochloride.
E. Strophanthine.
19. A 40-year-old male was delivered to the hospital with acute attack of hepatic colic, which is accompanied by sharp pain. What drug should be introduced first of all?
*A. Atropine.
B. Codeine.
C. Analginum (metamizole).
D. Pentazocine.
E. Morphine.
20. A patient with complaints of dryness in the mouth, photophobia, and vision violation was admitted to the reception-room. Skin is hyperemic, dry, pupils are dilated, tachycardia. Poisoning with belladonna alkaloids was diagnosed on further examination. What drug should be prescribed?
*A. Proserine.
B. Pilocarpine.
C. Armine.
D. Diazepam.
E. Dipyroxim.
21. A 50-year-old male farm worker has been brought to the emergency room. He was found confused in the orchard and since then has remained unconscious. His heart rate is 45 and his blood pressure is 80/40 mm Hg. He is sweating and salivating profusely. Which of the following should be prescribed?
*A. Atropine.
B. Proserine.
C. Physostigmine.
D. Noradrenaline.
E. Pentamine.
22. Pirenzepine was prescribed to a woman for stomach ulcer treatment. What pharmacological group can this medication be referred to?
*A. Selective M1-cholinergic antagonists.
B. Acetylcholinesterase reactivators.
C. b-adrenergic blockers.
D. Selective a1-adrenergic blockers.
E. Local anaesthetics.
23. A patient with glaucoma appealed to a pharmacist with the request to give her atropine sulfate eye drops, but she was explained, that atropine sulfate is contraindicated in case of glaucoma. Why?
*A. It increases intraocular pressure.
B. It leads to a paralysis of accommodation.
C. It dilates pupils.
D. It reduces distance of vision.
E. It narrows the field of vision.
24. A doctor has been appealed to by a man who has preliminary been examined by an ophthalmologist. Patient complains of thirst and bad vision of close subjects. Objectively he demonstrates tachypnoea, mydriatic pupils, general excitation, garrulity, though the speech is obscure. Arterial pressure is 110/70, pulse is 110 per minute. The overdose of which drug can cause these symptoms?
*A. Atropini sulfas.
B. Morphini hydrochloridum.
C. Ephedrini hydrochloridum.
D. Aminazinum.
E. Coffeinum-natrii benzoas.
25. Sharp pain in the eye area of patient has developed after the use of atropine in eye drops during examination of the eye fundus. From anamnesis it became clear that patient suffers from mild form of glaucoma. Why atropine is contraindicative at glaucoma?
*A. Atropine increases intraoccular pressure.
B. Atropine causes paralysis of accommodation.
C. Atropine narrows pupils.
D. Atropine affects vision.
E. Atropine oppresses eye reflexes.
26. The victim with acute poisoning by fly-agaric was delivered to urgent department. What drug should be prescribed to him?
*A. Atropine sulfate.
B. Dithylinum.
C. Diazolinum.
D. Furacilinum.
E. Omeprazole.
27. A patient suffering from myasthenia has been administered proserin. After its administration the patient has got nausea, diarrhoea, twitch of tongue and skeletal muscles. What drug would help to eliminate the intoxication?
*A. Atropine sulfate.
B. Mesatonum.
C. Pyridostigmine bromide.
D. Isadrine.
E. Physostigmine.
28. A patient with drug intoxication presented with the dryness of oral mucous membrane and mydriatic pupils. Such action of this drug is associated with the following effect:
*A. Muscarinic cholinoceptor block.
B. Nicotinic cholinoceptor stimulation.
C. Adrenoceptor stimulation.
D. Muscarinic cholinoceptor stimulation.
E. Adrenoceptor block.
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